Alleviation of carbon tetrachloride-induced hepatocellular damage and oxidative stress with a leaf extract of Glyphae brevis (Tiliaceae)
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منابع مشابه
Alleviation of Cisplatin-Induced Hepatotoxic Damage: the Synergistic Effect of Morin and Hesperidin against Oxidative Stress
Background and objectives: A key aspect of cisplatin-induced hepatotoxicity is oxidative stress. The current study was conducted to show, for the first time, the restoring and synergistic effects of morin and hesperidin against oxidative stress in hepatotoxicity. Methods: Fourty-two Wistar albino rats were randomly divided into seven groups: group A (control), ...
متن کاملThe hepatocurative effects of Cynara scolymus L. leaf extract on carbon tetrachloride-induced oxidative stress and hepatic injury in rats
Cynara scolymus is a pharmacologically important medicinal plant containing phenolic acids and flavonoids. Experimental studies indicate antioxidant and hepatoprotective effects of C. scolymus but there have been no studies about therapeutic effects of liver diseases yet. In the present study, hepatocurative effects of C. scolymus leaf extract on carbon tetrachloride (CCl4)-induced oxidative st...
متن کاملMechanism of carbon tetrachloride-induced hepatotoxicity. Hepatocellular damage by reactive carbon tetrachloride metabolites.
CCl4-induced liver damage was modeled in monolayer cultures of rat primary hepatocytes with a focus on involvement of covalent binding of CCl4 metabolites to cell components and/or peroxidative damage as the cause of injury. (1) Covalent binding of 14C-labeled metabolites was detected in hepatocytes immediately after exposure to CCl4. (2) Low oxygen partial pressure increased the reductive meta...
متن کاملProtective effects of Lactuca sativa ethanolic extract on carbon tetrachloride induced oxidative damage in rats
*Corresponding author: Mohamed Fawzy Ramadan, Associate Professor, Biochemistry Department, Faculty of Agriculture, Zagazig University, Zagazig 44519, Zagazig, Egypt. Tel: +20-055-2320282, 002-055-2313940 Fax: +20-055 2287567, 002-055-2345452 E-mail: [email protected] or [email protected] Foundation Project: Supported by Faculty of Agriculture, Zagazig University (Project Number 34-2...
متن کاملProtective Effect of Coccinia Indica Leaf Extract against Alcohol Combined with Carbon Tetrachloride and Paracetamol Induced Liver Damage in Rats
Liver is a major metabolic organ affected by various toxins and chemicals. So the potential therapeutic agent is needed for the treatment of liver diseases. Natural products are the best source of remedies for the treatment of all diseases.The aim of our study was to investigate the effect of leaf extract of Coccinia indica against Alcohol combines with CCl4 and Paracetamol induced hepatotoxici...
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ژورنال
عنوان ژورنال: Journal of Basic and Clinical Physiology and Pharmacology
سال: 2018
ISSN: 2191-0286,0792-6855
DOI: 10.1515/jbcpp-2017-0058